Tuesday, December 6, 2011

FDA staff find small subset behind Inlyta effect (Reuters)

WASHINGTON (Reuters) ? Slower tumor growth in kidney cancer patients taking Pfizer Inc's drug Inlyta in trial was driven by a small subset of patients who are likely rare in the United States, Food and Drug Administration researchers said.

In review documents released on Monday, FDA staff found Inlyta having a safety profile similar to other drugs in its class. But they expressed concerns that progression of the disease was better in the patients previously treated by cytokines, which are rarely taken in the United States, than a more common medicine sunitinib.

Pfizer markets sunitinib under the brand Sutent.

Inlyta, clinically known as axitinib, is one of Pfizer's most important experimental medicines. An oral drug, Inlyta inhibits certain receptors that can influence tumor growth and progression of cancer.

Pfizer shares rose almost 1 percent to $20.08 in morning trading on the New York Stock Exchange.

(Reporting by Alina Selyukh in Washington)

Source: http://us.rd.yahoo.com/dailynews/rss/diseases/*http%3A//news.yahoo.com/s/nm/20111205/hl_nm/us_pfizer_fda

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Monday, December 5, 2011

92% Drive

Driver: If I drive for you, you give me a time and a place. I give you a five-minute window, anything happens in that five minutes and I'm yours no matter what.I tend to spend most of my time during a film figuring out what is flawed about it, but every once in a while, I am graced with a film where I can sit down and enjoy every minute of it. That's exactly what I got from Drive, a hyper-violent, gruesome, tense, and throughly entertaining film throughout. Not only was it supremely entertaining, it is also wholly original; as well as a masterful lead from indie-guru Ryan Gosling, stylish direction from Nicolas Winding Refn, who all contribute to making Drive one of the best films of the year. Ryan Gosling stars as Driver, who spends his days as a Hollywood stunt driver and a worker and a car repair shop. By night, Driver drives (yep, there will be probably hundreds of uses of the word "drive" in this review) criminals to and from their heist. When a heist involving his neighbors husband who was recently released from prison goes wrong, and the criminals find out who Driver really is, it's time for him to take charge of the situation and to do whatever it takes to get payback and stay alive. I guess the first thing I'll talk about is the fact that it in no way is an action film. It is a tense drama that features some strong violence. There are some defining action moments, but this is mostly a slow paced thriller, which was definitely a brilliant aspect pertaining to the film's style. The first hour or so consists only of strong character development, and a lot of leading up to the last forty minutes where a lot of mindless yet awesome action occurs. The action sequences are arranged quite well. The whole film itself has sort of an art house feel to it, and this action seems pretty gritty, and pretty realistic if I may say. Don't mistake this for another Fast and Furious film, this is its own movie, and the action here is something [similar] to what would really happen in a situation like this. The only thing that was over exemplified was the blood, there was a lot of blood. For anyone who enjoys gruesome films, this is right up your alley. Even if you are into superhero movies, this is for you; according to actor Ryan Gosling (found HERE).Speaking of Ryan Gosling, 2011 seems to be the year of Gosling, as he's starred in the hit romantic comedy Crazy, Stupid, Love (my review can be found HERE), and the upcoming Clooney film The Ides of March. He was also in Blue Valentine, The Notebook, and Lars and the Real Girl. Drive is his best film so far. Even judging by the original trailer, you could tell Gosling would be great. He was spectacular. Seeing Gosling's character strolling down the street, blood stains all over his super-cool Scorpion Jacket is a pleasure to watch. The supporting cast are also definitely great too. I'll start with my favorite of them; Albert Brooks, who switched over from his usual good guy character to a bad-ass man-in-charge, and Brooks' performance is masterful, scary, and sheds some blood. Hellboy star Ron Perlman is also a favorite of mine in this, and is a great addition to an already well-picked cast. The film featured other great performances from Bryan Cranston, Oscar Isaac, Christina Hendricks, and Carey Mulligan.The film gets it's amazingly original arthouse style due to the fantastic direction from acclaimed Danish director Nicolas Winding Refn (Bronson, Valhalla Rising, and another Ryan Gosling film Only God Forgives). Nicolas's directing style is wholly unique, and wholly original, as well as wholly entertaining, and wholly beautiful. What I love the most about his directing style, as far as indie films go, was not only his lack of complexity (I mean that in a good way), but his arthouse style was very unique. I was absolutely mesmerized by it; it is almost impossible to describe, you have to see it to believe it.Drive is one of the best experiences I've had watching a film. It's always good when a movie ends, and you realize that it was flawless (as well as giving it a huge round of applause, as my theater did). Drive is a very fun, gory, gruesome, but has a sense of tense drama moments (which basically consists of the entire first hour until the hyper-violent era of the film occurs), as well as a mesmerizing performance from Ryan Gosling, and great direction from Nicolas Winding Refn, who all make this film that is destined to become a classic.Driver: When you get your money, his debt's paid. He's out for good and you never go near his family again. You understand?

July 30, 2011

Source: http://www.rottentomatoes.com/m/drive_2011/

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Sunday, December 4, 2011

Amazon tablet now second best after Apple

December 3, 2011 11:08 am

The 200-dollar tablet was only released last month, and is on course to sell 3.9 million units in its first quarter on the market, giving it almost 14 per cent of the global tablet business, IHS said.

"Nearly two years after Apple Inc. rolled out the iPad, a competitor has finally developed an alternative which looks like it might have enough of Apple?s secret sauce to succeed," said Rhoda Alexander, the senior manager for tablet research at IHS.

Amazon still has a long way to go to match Apple, which controls 65.6 per cent of the market, down from 70 per cent in the previous quarter. The company also took a bite out of Samsung?s share of the world tablet market, which fell to 4.8 per cent from 7.8 per cent in the third quarter.

Amazon?s tablet is much smaller and offers fewer features than the iPad, but has attracted millions of customers since it costs less than half the 500 dollars that buyers must pay with for the cheapest of the Apple tablets. It also offers a richly integrated ecosystem, allowing users to easily access Amazon?s massive online store as well as its video, book and music services.//DPA

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Source: http://feedproxy.google.com/~r/Nationmultimediacom-Breakingnews/~3/RZnSpxexrXQ/Amazon-tablet-now-second-best-after-Apple-30171199.html

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Man sentenced for killing wife; she strangled son (AP)

BRENTWOOD, N.H. ? A New Hampshire man was sentenced to 15 to 30 years in prison Friday for beating his wife to death with a flashlight after he came home to find she had strangled their 4-year-old son with a ribbon and tried to kill their 7-year-old daughter.

Christopher Smeltzer, 39, pleaded guilty to killing Mara Pappalardo, who was hospitalized several times for mental illness. Prosecutors say she was paranoid, obsessed with death and convinced her husband and mother-in-law were plotting to take her children away.

"When I walked into the room, as soon as I saw my son, I knew something was very wrong," Smeltzer told the court before he was sentenced, his voice breaking at times. "I knew he was dead. And I lost all control. Enraged, I struck my wife. I did something that was not going to bring my son back."

Smeltzer was charged with second-degree murder in the November 2010 killing at their Auburn home. Prosecutors later downgraded that to manslaughter, saying he was provoked by the sight of the still bodies of their son, Mason, and daughter, Mercey.

He arrived home Nov. 7 to find Mason with a ribbon around his neck and Mercey with a scarf around hers. He thought both were dead. Pappalardo tied a blue rope around her own neck in an attempt to kill herself, although prosecutors said she died from both strangulation and Smeltzer hitting her in the head with the flashlight.

Smeltzer did not call 911. Instead, he snipped the ribbon off Mason's neck and removed the scarf from Mercey's. Then he took all the pills he could find ? painkillers, sleeping aids and methadone ? and lay down on the couch to die.

He was awakened the next morning by Mercey, who asked if her mother and brother were breathing and requested a cup of tea. He made her one, then called his father and 911.

Smeltzer, who was wearing handcuffs Friday, wept while talking about how much he misses his son. "I miss my wife as well," he said. "I miss Mara's smile and heart and the way she played with our children."

He apologized to her family. "I brought more pain and sorrow," he said, adding he wishes every day he had a rewind button.

Judge Tina Nadeau said if Smeltzer earns a college degree and completes anger management behind bars, his minimum sentence would be reduced to 10 years.

Before Smeltzer spoke, a court-appointed guardian representing Mercey played a recording of the child reading a letter to the judge in which she said her father killed her mother and Mason. "If he loves me, why would he try to kill me?" she said. "If my daddy gets out, how will I keep safe? Please keep him in jail for the rest of his life."

After that, prosecutor Jane Young got up and said the recording is contrary to statements Mercey has made in the past, in counseling and interviews. She repeatedly had said her father had taken the scarf off of her neck. She has said she remembers her mother carrying her into the bedroom, but doesn't remember what happened next, Young said.

Prosecutors said there is no evidence that Smeltzer killed Mason.

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20111202/ap_on_re_us/us_mother_son_deaths

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Saturday, December 3, 2011

S.Africa: Funds raised to fight rhino poaching (AP)

JOHANNESBURG ? A fundraising campaign aimed at putting rhino poachers in jail was welcomed Friday by a South African conservationist.

Michael Knight, head of park planning and development for South Africa's national parks department, said money raised by the Florida-based International Rhino Federation would be used to support such efforts as teaching park employees how to safeguard evidence at crime scenes.

More South African rhinos were poached ? 341 ? in the first 10 months of 2011 than in all of 2010, which was a record poaching year with 333 animals lost. The International Rhino Federation project is for parks in South Africa and neighboring Zimbabwe, which also has seen increased poaching.

An Asian economic boom in recent years is believed to be behind the spike in poaching, with a growing middle class in countries like China and Vietnam able to afford exotic purported remedies like powdered rhino horn.

"We're losing animals like crazy," Knight, who also chairs the rhino specialist group of the International Union for Conservation of Nature, said in an interview. "But the prosecutions are falling way behind."

Knight said police in isolated areas of South Africa are not always experienced in investigating environmental crime. He said rangers and others would be trained to support police and prosecutors.

In court, he said, "You need to have the most up-to-date information, you need to have the most convincing arguments."

The federation launched its fundraising this week. Donations will fund training in collecting evidence and information. The federation also plans to distribute basic crime scene kits containing cameras, fingerprinting materials and evidence bags.

In an interview, federation director Susie Ellis said that an anonymous donor kicked off the fund with $25,000. She said she spoke with South African security officials in March about how best to use the money.

"It's a small project that we hope will have a big impact," she said, adding tthat he first training session is set for early February in South Africa.

____

Online:

http://www.rhinos-irf.org

____

Donna Bryson can be reached on http://twitter.com/dbrysonAP

Source: http://us.rd.yahoo.com/dailynews/rss/science/*http%3A//news.yahoo.com/s/ap/20111202/ap_on_re_af/af_south_africa_rhino_poaching

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Friday, December 2, 2011

Egypt's Islamists poised to dominate parliament (AP)

CAIRO ? Islamists appear to have taken a strong majority of seats in the first round of Egypt's first parliamentary vote since Hosni Mubarak's ouster, a trend that if confirmed would give religious parties a popular mandate in the struggle to win control from the ruling military and ultimately reshape a key U.S. ally.

Final results, expected Friday, will be the clearest indication in decades of Egyptians' true political views and give the long-banned Muslim Brotherhood a major role in the country's first freely elected parliament. An Islamist majority could also herald a greater role for conservative Islam in Egyptian social life and shifts in foreign policy, especially toward Israel and the Palestinians.

The showing in Egypt ? long considered a linchpin of regional stability ? would be the clearest signal yet that parties and candidates connected to political Islam will emerge as the main beneficiaries of this year's Arab Spring uprisings.

Tunisia and Morocco have both elected Islamist majorities to parliament, and while Libya has yet to announce dates for its first elections, Islamist groups have emerged as a strong force there since rebels overthrew Moammar Gadhafi in August. They also play a strong opposition role in Yemen.

Judges overseeing the Egyptian vote count said Thursday that near-complete results show the Muslim Brotherhood, the country's largest and best organized political group, could take as many as 45 percent of the contested seats.

In addition to the Muslim Brotherhood wins, parties backed by ultraconservative Salafist Muslims looked poised to take 20 percent, giving Islamist parties a striking majority in the first round of voting in key districts, including Cairo and Alexandria.

Similar results in the remaining rounds would give Islamist parties a majority in parliament, which many believe they will use to steer the long-secular U.S. ally in a more religiously conservative direction.

The Islamist victories came at the expense of a coalition of liberal parties called the Egyptian block, the group most closely linked to the youth activists who launched the anti-Mubarak uprising ? and which is expected to win only about 20 percent of seats.

In Egypt, the Brotherhood was officially banned and suppressed for decades, but built a nationwide network of activists who focused on providing services to the poor. After Mubarak's fall, the group campaigned as the Freedom and Justice Party, their organization and the Brotherhood's name-recognition giving them a big advantage over newly formed liberal parties.

The election also provided an opening for the Salafist Muslims whose strict Islamic practice is similar to that in Saudi Arabia. While the Muslim Brotherhood has said it will preserve individual rights, Salafi groups are not shy about their ambition to turn Egypt into a state where women must dress modestly and TV content deemed offensive will be banned.

The Brotherhood's leadership has so far avoided defining the ruling coalition it will seek to build. And during the campaign, it often avoided strict Islamist rhetoric in favor of more inclusive messages about social equality and clean government.

Critics, however, worry that once in power, the group will band together with its Islamist allies to impose stricter social codes. Many in Egypt's Coptic Christian minority fear they'll face new restrictions on building churches.

The Obama administration has lauded the elections, saying it will cooperate with the victors, no matter what their persuasion.

Israel, which has long considered its peace treaty with Egypt a buffer against regional war, worries Islamists will be less cooperative than Mubarak was. Israel is highly unpopular in most of Egyptian society, and Brotherhood leaders have suggested they'll review Egypt's relationship with the Jewish state. They may also deepen ties to Hamas, the militant group that rules the Gaza Strip.

This week's vote, held in seven provinces, will determine about 30 percent of the 498 seats in the People's Assembly, parliament's lower house. Two more rounds, ending in January, will cover Egypt's other 20 provinces. Three more rounds lasting until March will elect the less powerful upper house.

Egypt's election commission said that unexpectedly large voter turnout in the first round had slowed the count and that results, initially expected Thursday, would be announced Friday.

Participation figures have not been released, but Maj. Gen. Ismail Etman of the ruling military council estimated that 70 percent of eligible people voted.

The power the new legislature will have remains unclear.

Several members of the Supreme Council of the Armed Forces, which took control of the country when Mubarak fell, have said the new parliament will not appoint the prime minister or have power to dismiss the Cabinet. The military has also said it will appoint 80 of the 100-member panel charged with drafting a new constitution.

The Brotherhood is expected to challenge the army on these issues, and a strong showing in the elections will boost its mandate to do so. The group's leaders have already said they will form a coalition government that will choose its own prime minister.

The military has other plans. Last week, military council head Hussein Tantawi appointed a Mubarak-era prime minister to head a new government. Kamal el-Ganzouri is expected to announce its members Saturday.

His government will not likely serve for more than a few months, and groups pushing for a faster transition to civilian rule consider it a mere front for continued military rule.

The trial of some 12,000 civilians before military courts this year has soured many on the military, and an attempt to clear the square of a sit-in by families of those killed by security forces two weeks ago sparked days of clashes in which some 40 more were killed.

This week's large voter turnout, however, could undermine the call for renewed protest more than any military statement, as many Egyptians seem to have placed their hopes in the political process.

Some youth leaders acknowledged this.

"The revolution has partially ended with the holding of the elections," said Ahmed Imam, a youth leader in the anti-Mubarak uprising. "The conflict now will not be between Tahrir and the military, but between the military and the next parliament. This will steal the spotlight from our revolutionary struggle."

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20111202/ap_on_re_mi_ea/ml_egypt

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Obama, Clinton to announce energy saving program (AP)

WASHINGTON ? Enlisting former President Bill Clinton as a partner, President Barack Obama is announcing a $4 billion effort to increase the energy efficiency of government and private sector buildings, aiming for fuel savings and job creation at no cost to taxpayers.

The proposal, to be announced by Obama and Clinton on Friday, would upgrade buildings over the next two years with a goal of improving energy performance by 20 percent by 2020. The federal government would commit $2 billion to the effort and a coalition of corporations, labor unions, universities and local governments would undertake the other half.

The contractors who undertake the work would be paid with realized energy savings, thus requiring no up-front federal expenditure.

"Upgrading the energy efficiency of America's buildings is one of the fastest, easiest and cheapest ways to save money, cut down on harmful pollution and create good jobs right now," Obama said in a statement.

The president will make the announcement after touring a downtown Washington office building whose owners have agreed to make more energy efficient under Obama's plan.

The program, known as Energy Savings Performance Contracts, has been in place since the Clinton administration but has been little used. Obama's announcement is yet another in a string of White House initiatives designed to address the current weak economy without having to seek congressional approval.

Gene Sperling, director of the White House National Economic Council, said private economic analyses indicate that the $4 billion plan could generate about 50,000 jobs over two years.

The program builds on an initiative that Obama launched in February and that Clinton led through his Clinton Foundation to get the private sector to invest in greater energy efficiency. Clinton already had announced commitments of $500 million in energy efficiency projects in June.

The Obama administration helped finance private sector energy upgrades through its 2009 stimulus program. But that money has begun to run out, and advocates of the new initiative say they hope the effort fills the void.

Joining Obama and Clinton will be Thomas Donohue, the president and CEO of the U.S. Chamber of Commerce, a long-time proponent of the Energy Saving Performance Contracts.

"We have been pushing the ESPC program for more than a decade because this holds tremendous potential," Donohue said in a statement. "Despite the benefits of ESPCs, the program has been grossly underutilized."

Source: http://us.rd.yahoo.com/dailynews/rss/science/*http%3A//news.yahoo.com/s/ap/20111202/ap_on_go_pr_wh/us_obama_energy_efficiency

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